We are excited to announce the launch of the Global South Healthcare Journal, a pioneering research publication dedicated to addressing the unique challenges and opportunities in healthcare within the Global South. The inaugural issue starts with an interesting editorial highlighting India’s Role in Strengthening Healthcare Across the Global South, an original research on Global Public Health Emergencies: Insights for Future Preparedness based on India’s Response to the COVID-19 Pandemic. The issue has other impactful reviews on Air Pollution and Respiratory health of children with Focus on India, Climate Change and One Health, Ladybird Beetles as Nature's Allies in Pest Control, Role of Indigenous Knowledge in the Siddi Health System, and Applications of Generative AI in Healthcare. The issue also presents a Summary of Global South Research Collaborative (GSRC) Launch & Pandemic Accord.