Unlocking the Potential of Dental Pulp Stem Cells: Neuroprotective and Regenerative Insights for Treating Neurological Diseases
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Abstract
Neurological illnesses impose a significant global health burden, with limited treatment options currently available. Recent advances in regenerative medicine have sparked interest in exploring various stem cell sources for neurological disorder treatment. Dental pulp stem cells (DPSCs) have emerged as a promising option due to their neural crest origin, multilineage differentiation capability, and accessibility through routine dental procedures. This review delves into our current understanding of DPSC function concerning neurological diseases, examining their neuroprotective and regenerative potential. It elucidates how DPSCs can differentiate into neural-like cells and release trophic substances that enhance the survival and functionality of neurons. Furthermore, the review explores the mechanisms underlying DPSCs' neuroprotective effects, shedding light on their immunomodulatory characteristics and ability to regulate inflammatory responses in the central nervous system. The challenges and potential avenues for utilizing DPSCs in neurological disorder treatment are also discussed, emphasizing the importance of large-scale clinical trials, ethical considerations, and well-defined procedures.
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