The issue brings the editorial on Periodontal plastic surgery and reconstruction and guest editorials describing the current landscape of oral and maxillofacial surgery and regenerative medicine in dentistry. Further, it publishes research articles on microsatellite instability and loss of heterozygosity in OSCC patients, and prevalence of periodontal disease, oral mucosal lesions and oral habits, alongwith a case series on Diastema closure and esthetic rehabilitation with peg-shaped laterals.