Approach to a Child with Cleft Lip and Palate (CLP) – Perinatal Management: A Narrative Review
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Abstract
Cleft lip and palate (CLP) are among the most common congenital craniofacial anomalies, affecting approximately 1 in 700 births globally. This narrative review discusses the multifactorial etiology of CLP, including genetic predisposition and environmental triggers such as maternal smoking, alcohol use, and nutritional deficiencies. The importance of early diagnosis through prenatal ultrasonography and the role of a multidisciplinary approach in managing CLP are emphasized. Early identification allows for timely intervention, specialized feeding methods, and parental counseling, which can significantly reduce anxiety and improve outcomes.
The review highlights the critical role of a multidisciplinary cleft team, comprising plastic surgeons, pediatricians, speech therapists, orthodontists, and other specialists, in providing comprehensive care. This team approach ensures coordinated surgical repairs, ongoing support for feeding, hearing, speech development, and psychosocial well-being. The manuscript also explores the various surgical techniques for lip and palate repair, the use of specialized feeding bottles, and the importance of speech therapy and orthodontic care in the long-term management of CLP.
Additionally, the review addresses the challenges faced in India, where a substantial number of infants are born with clefts each year. It underscores the need for raising awareness, improving access to specialized care, and supporting families through government programs and NGO initiatives. The future trends in cleft care, including tissue engineering, 3D printing, and the application of artificial intelligence, are also discussed, offering hope for improved outcomes and reduced treatment burdens.
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References
Stroustrup Smith A, Estroff JA, Barnewolt CE, Mulliken JB, Levine D. Prenatal diagnosis of cleft lip and cleft palate using MRI. AJR Am J Roentgenol. 2004;183(1):229-235. doi:10.2214/ajr.183.1.1830229
Mossey P, Little J. Addressing the challenges of cleft lip and palate research in India. Indian J Plast Surg. 2009;42 Suppl(Suppl):S9-S18. doi:10.4103/0970-0358.57182
Putri, F. A., Pattamatta, M., Anita, S. E. S., & Maulina, T. (2024). The Global Occurrences of Cleft Lip and Palate in Pediatric Patients and Their Association with Demographic Factors: A Narrative Review. Children, 11(3), 322. https://doi.org/10.3390/children11030322
Almoammar KA. Harnessing the Power of Artificial Intelligence in Cleft Lip and Palate: An In-Depth Analysis from Diagnosis to Treatment, a Comprehensive Review. Children (Basel). 2024;11(2):140. Published 2024 Jan 23. doi:10.3390/children11020140.
Hubbard BA, Baker CL, Muzaffar AR. Prenatal counseling's effect on rates of neonatal intensive care admission for feeding problems cleft lip/palate infants. Mo Med. 2012;109(2):153-156
Neogi SB, Singh S, Pallepogula DR, et al. Risk factors for orofacial clefts in India: A case-control study. Birth Defects Res. 2017;109(16):1284-1291. doi:10.1002/bdr2.1073
Maarse, W., Pistorius, L.R., Van Eeten, W.K., Breugem, C.C., Kon, M., Van den Boogaard, M.J.H. and Mink van Der Molen, A.B. (2011), Prenatal ultrasound screening for orofacial clefts. Ultrasound Obstet Gynecol, 38: 434-439. https://doi.org/10.1002/uog.8895
Maarse, W., Bergé, S.J., Pistorius, L., van Barneveld, T., Kon, M., Breugem, C. and Mink van der Molen, A.B. (2010), Diagnostic accuracy of transabdominal ultrasound in detecting prenatal cleft lip and palate: a systematic review. Ultrasound Obstet Gynecol, 35: 495-502. https://doi.org/10.1002/uog.7472
Smarius B, Loozen C, Manten W, Bekker M, Pistorius L, Breugem C. Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology. World J Methodol. 2017;7(3):93-100. Published 2017 Sep 26. doi:10.5662/wjm.v7.i3.93
Caring for babies born with cleft lip or cleft palate: AAP report explained. (n.d.). healthychildren.org. Retrieved March 2, 2025, from https://www.healthychildren.org/English/health-issues/conditions/Cleft-Craniofacial/Pages/Cleft-Lip-and-Palate-Parent-FAQs.aspx#:~:text=,of%20children%20born%20with
Prenatal counseling for cleft and craniofacial conditions. (n.d.). Children’s Hospital of Richmond at VCU. Retrieved March 2, 2025, from https://www.chrichmond.org/services/center-for-craniofacial-care/our-services/prenatal-counseling/#:~:text=Prenatal%20counseling%20,services%20and%20programs%20available
Prenatal counseling. (n.d.). Seattle Children’s Hospital. Retrieved March 2, 2025, from https://www.seattlechildrens.org/clinics/craniofacial/services/prenatal-counseling/#:~:text=Prenatal%20Counseling%20,We%20will%20give%20you
Nasopharyngeal Tube NPT modified for Pierre Robin Sequence PRS. (n.d.). The Royal Children’s Hospital Melbourne. Retrieved March 2, 2025, from https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Nasopharyngeal_tube_NPT_modified_for_pierre_robin_sequence_PRS/#:~:text=Nasopharyngeal%20tube%20NPT%20modified%20for,babies%20with%20Pierre%20Robin%20Sequence
Aqrabawi HE. Facial cleft and associated anomalies: incidence among infants at a Jordanian medical centre. East Mediterr Health J. 2008;14(2):356-359
Feeding tips for care givers of child with CLEFT LIP AND PALATE. (n.d.). All India Institute of Speech & Hearing. https://aiishmysore.in/pdf/3_FEEDING%20TIPS.pdf.
Gopalakrishna A, Agrawal K. A status report on management of cleft lip and palate in India. Indian J Plast Surg. 2010;43(1):66-75. doi:10.4103/0970-0358.63938.
Bessell A, Hooper L, Shaw WC, Reilly S, Reid J, Glenny AM. Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate. Cochrane Database Syst Rev. 2011;2011(2):CD003315. Published 2011 Feb 16. doi:10.1002/14651858.CD003315.pub3
Gupta, R. G., Shah, A., & Kireeti, A. (n.d.). STANDARD TREATMENT GUIDELINES 2022 Cleft Lip and Palate. Retrieved March 2, 2025, from https://iapindia.org/pdf/Ch-128-Cleft-Lip-and-Palate.pdf.
Oliver JD, Jia S, Halpern LR, et al. Innovative Molecular and Cellular Therapeutics in Cleft Palate Tissue Engineering. Tissue Eng Part B Rev. 2021;27(3):215-237. doi:10.1089/ten.TEB.2020.0181
Sándor, G.K.B. (2015). Tissue engineering and regenerative medicine: evolving applications towards cleft lip and palate surgery. In Cleft lip and palate management (eds R.D. Bennun, J.F. Harfin, G.K.B. Sándor and D. Genecov). https://doi.org/10.1002/9781119050858.ch2
Dhillon H, Chaudhari PK, Dhingra K, et al. Current Applications of Artificial Intelligence in Cleft Care: A Scoping Review. Front Med (Lausanne). 2021;8:676490. Published 2021 Jul 28. doi:10.3389/fmed.2021.676490