Hypertension and Alzheimer’s Disease: Unravelling the Connection
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Abstract
Hypertension, a well-established risk factor for cardiovascular diseases, has emerged as a significant contributor to Alzheimer's disease (AD) pathogenesis. This review explores the pathophysiological mechanisms through which hypertension exacerbates neurodegeneration, with a focus on cerebrovascular dysfunction, blood-brain barrier (BBB) disruption, neuroinflammation, oxidative stress, and amyloid-beta accumulation. Additionally, the potential role of antihypertensive treatments in mitigating cognitive decline and slowing AD progression is examined. Understanding the molecular pathways linking hypertension to AD could facilitate the development of therapeutic interventions aimed at preventing or delaying dementia.
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