Comparative Profile of Ischemic and Hemorrhagic Stroke in Diabetic and Hypertensive Patients: A Prospective Observational Study from an Indian Emergency Department

Main Article Content

Shubhi Shubhangi Bhatnagar
Nayan Sriramula
Gagan Srivastava

Abstract

Introduction: Hypertension and diabetes mellitus are major risk factors for stroke. This study compared stroke subtype, severity, and in-hospital outcomes between diabetic and hypertensive patients in an Indian emergency department.


Methods: A prospective observational study of 115 adults with radiologically confirmed stroke and documented diabetes or hypertension was conducted. Stroke type was determined by CT scan, and severity was assessed using the NIHSS.


Results: Ischemic stroke was predominant overall (74.8%). Hemorrhagic stroke was significantly more common in hypertensive patients, while ischemic stroke predominated among diabetics (p < 0.01). Stroke severity and in-hospital mortality did not differ significantly between groups.


Conclusion: Hypertension is more strongly associated with hemorrhagic stroke, whereas diabetes predominantly predisposes to ischemic stroke. However, stroke severity and short-term hospital outcomes were comparable between the two groups, emphasizing the need for effective risk-factor control in both conditions.

Metrics

Metrics Loading ...

Article Details

How to Cite
Bhatnagar, S. S., Sriramula, N., & Srivastava, G. (2026). Comparative Profile of Ischemic and Hemorrhagic Stroke in Diabetic and Hypertensive Patients: A Prospective Observational Study from an Indian Emergency Department. Hypertension Journal, 12(1), 14–19. https://doi.org/10.61081/htnj/26v12i104
Section
Research Articles

References

Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, Abbasifard M, Abbasi-Kangevari M, Abd-Allah F, Abedi V, Abualhasan A. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology. 2021 Oct 1;20(10):795-820.

O'Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, Rao-Melacini P, Zhang X, Pais P, Agapay S, Lopez-Jaramillo P. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. The lancet. 2016 Aug 20;388(10046):761-75.

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. The lancet. 2005 Jan 15;365(9455):217-23.

Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1• 9 million people. The lancet Diabetes & endocrinology. 2015 Feb 1;3(2):105-13.

Janghorbani M, Hu FB, Willett WC, Li TY, Manson JE, Logroscino G, Rexrode KM. Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses’ Health Study. Diabetes care. 2007 Jul 1;30(7):1730-5.

Bhandare SS, Roy S, Mani UA, Gautam K. Ophthalmological and radiological findings in patients of hypertensive crisis reporting to an intensive care setting. Heart India 2023;11:109‑12.

Mani UA, Kumar M, Abbas H, Gupta P, Abbas H, Alam J, Alam S, Akram Y, Raza SH. Inhospital Ischemic Stroke with Typical and Atypical Risk Factors. Journal of The Association of Physicians of India. 2025 Feb;73(2):e10.

Verma S, Verma A, Kanodia N, Srivastava S, Ansari S, Tewari A, Maheswari A, Srivastava M. Exploring the Synergy Between Hyperuricemia, Obesity, and Hypertension: Evidence from Urban India. Hypertension Journal. 2024 Apr 25;10(1):13-8.

Tiwari R, Verma S, Verma N, Singh S, Yadav S, Nishat N, Mittal A. Navigating the Intersection of Hypertension and Erectile Dysfunction: Advances in Diagnosis, Treatment, and Lifestyle Management. Hypertension Journal. 2023 May 30;9(1):10-4.

Mani UA, Ansari D, Bhot FB, Sada E, Ursekar R. Auto-amputation of an Entire Foot with Ankle in a Diabetic Patient. Advanced Journal of Emergency Medicine. 2019 Aug 17;3(4):e47.

Tiwari R, Singh N, Singh S, Bajpai M, Verma S, Singh Sr N. Interplay of adiponectin with glycemic and metabolic risk metrics in patients with diabetes. Cureus. 2024 Sep 30;16(9).

Verma S, Tiwari R, Verma N, Singh S, Sharma A. Anthropometry and blood biomarkers of diabetes and their possible association with obesity and metabolic syndrome. Journal of Diabetes & Metabolic Disorders. 2024 Jun;23(1):509-17.

Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality. The Lancet. 2003 Apr 19;361(9366):1391-2.

O'donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. The Lancet. 2010 Jul 10;376(9735):112-23.

Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. New England Journal of Medicine. 2001 May 10;344(19):1450-60.

Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. The lancet. 2010 Jun 26;375(9733):2215-22.

Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, Hadden D, Turner RC, Holman RR. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. bmj. 2000 Aug 12;321(7258):405-12.

Mani UA, Ghatak T, Sriramula N, Singh P, Yadav AR, Kumar M. Artificial Intelligence and Early Detection of Diabetic-Hypertensive Emergencies in the Emergency Room. Hypertension Journal. 2025;11(3):67–72.

Kumar M, Mani UA, Abbas H, Gupta P. High-Intensity Statins in Acute Coronary Syndrome Part I: A look at the Pharmacological Properties of Statins and Clinical Trials on Statins in ACS. Hypertension Journal. 2023; 9(2): 6-13.

Gupta P, Mani UA, Kumar M, Abbas H. High Intensity Statins in Acute Coronary Syndrome Part 2: A comparison of Atorvastatin and Rosuvastatin for use in ACS, Clinical trials in India and Place for statins in current guidelines. Hypertension Journal. 2023; 9(2): 14-19.

Adake D, Mani UA, Sada E, Shriyan S, Sarangan V, Ursekar R, Singh P. Incidence of Ventricular Fibrillation in Patients presenting with Myocardial Infarction. Hypertension Journal. 2023 Dec 28;9(4):16-7.

Adake D, Singh P, Mani UA, Ursekar R, Sada E, Bhot F, Shriyan SV, Sarangan V. A Clinical Overview of Patients Presenting to ER with Myocardial Infarction Assessed by ESI. National Journal of Emergency Medicine. 2023;1(2):48-51.

Adake D, Mani UA, Sarangan V, Shriyan S, Sada E, Bhot FB, Ursekar R, Singh P. Prevalence of Hepatitis B, Hepatitis C and HIV in Patients Presenting with Myocardial Infarction to Emergency Department. Indian Journal of Communicable Diseases/Volume. 2023 Jul;9(2).

Mani UA, Gautam K. Anti-Hypertensive Properties of Himalayan Raspberries: A Case Series of Five Hypertensive Patients. Hypertension Journal. 2025;11(3):73–75.

Mani UA, Kumar M, Abbas H, Gupta P. Stroke rehabilitation and the role of AI tools in physical recovery. Hypertension Journal. 2021;7(3):153-7.

Wang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, Zhou Y, Zhao X, Wang C, Liu L, Nguyen-Huynh MN. The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. International Journal of Stroke. 2011 Aug;6(4):355-61.

Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001 Oct 1;32(10):2426-32.

Tiwari R, Verma S, Verma N, Verma D, Narayan J. Correlation of serum uric acid levels with certain anthropometric parameters in prediabetic and drug-naive diabetic subjects. Annals of African Medicine. 2024 Jan 1;23(1):13-8.

Tiwari R, Singh S, Bajpai M, Verma N, Verma S. Impact of Osteocalcin on Glycemic Regulation and Insulin Sensitivity in Type 2 Diabetes Mellitus Patients. Cureus. 2024 Oct 17;16(10).

Anjana RM, Deepa M, Pradeepa R, Mahanta J, Narain K, Das HK, Adhikari P, Rao PV, Saboo B, Kumar A, Bhansali A. Prevalence of diabetes and prediabetes in 15 states of India: results from the ICMR–INDIAB population-based cross-sectional study. The lancet Diabetes & endocrinology. 2017 Aug 1;5(8):585-96.