Admission Hyperglycaemia as a Predictor of Stroke Severity and Mortality: Evidence from a Prospective Emergency Department Cohort

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Shubhi Shubhangi Bhatnagar
Nayan Sriramula
Gagan Srivastava

Abstract

Background: Admission hyperglycaemia is commonly observed in acute stroke and has been linked to poorer neurological outcomes. Its role as a prognostic marker in emergency settings warrants evaluation.


Objective: To assess the association between admission random blood sugar (RBS) levels and stroke severity, and to determine its relationship with in-hospital outcomes.


Methods: This prospective observational study included 115 adult patients with radiologically confirmed stroke presenting to a tertiary care emergency department. Admission RBS levels were recorded, and stroke severity was categorized using the National Institutes of Health Stroke Scale (NIHSS). Statistical analysis was performed with p < 0.05 considered significant.


Results: Mean admission RBS levels increased significantly with stroke severity, rising from 175.6 mg/dL in minor stroke to 216.5 mg/dL in severe stroke (p < 0.01). Overall in-hospital mortality was 7%.


Conclusion: Admission hyperglycaemia correlates positively with stroke severity and may serve as a simple, rapid prognostic marker in acute stroke care.

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How to Cite
Bhatnagar, S. S., Sriramula, N., & Srivastava, G. (2026). Admission Hyperglycaemia as a Predictor of Stroke Severity and Mortality: Evidence from a Prospective Emergency Department Cohort. Hypertension Journal, 12(1), 8–13. https://doi.org/10.61081/htnj/26v12i103
Section
Research Articles

References

Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001 Oct 1;32(10):2426-32.

Yong M, Kaste M. Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial. Stroke. 2008 Oct 1;39(10):2749-55.

Luitse MJ, Biessels GJ, Rutten GE, Kappelle LJ. Diabetes, hyperglycaemia, and acute ischaemic stroke. The Lancet Neurology. 2012 Mar 1;11(3):261-71.

Bruno A, Biller J, Adams Jr HP, Clarke WR, Woolson RF, Williams LS, Hansen MD. Acute blood glucose level and outcome from ischemic stroke. Neurology. 1999 Jan 1;52(2):280-.

Ntaios G, Egli M, Faouzi M, Michel P. J-shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke. 2010 Oct 1;41(10):2366-70.

Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T, FSR Investigators. Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry. Stroke. 2011 Oct;42(10):2788-94.

Mani UA, Kumar M, Abbas H, Gupta P, Abbas H, Alam J, Alam S, Akram Y, Raza SH. Inhospital Ischemic Stroke with Typical and Atypical Risk Factors. Journal of The Association of Physicians of India. 2025 Feb;73(2):e10.

Tiwari R, Singh N, Singh S, Bajpai M, Verma S, Singh Sr N. Interplay of adiponectin with glycemic and metabolic risk metrics in patients with diabetes. Cureus. 2024 Sep 30;16(9).

Verma S, Tiwari R, Verma N, Singh S, Sharma A. Anthropometry and blood biomarkers of diabetes and their possible association with obesity and metabolic syndrome. Journal of Diabetes & Metabolic Disorders. 2024 Jun;23(1):509-17.

Mani UA, Kumar M, Abbas H, Gupta P. Stroke rehabilitation and the role of AI tools in physical recovery. Hypertension Journal. 2021;7(3):153-7.

Mani UA, Ghatak T, Sriramula N, Singh P, Yadav AR, Kumar M. Artificial Intelligence and Early Detection of Diabetic-Hypertensive Emergencies in the Emergency Room. Hypertension Journal. 2025;11(3):67–72.

Bhandare SS, Roy S, Mani UA, Gautam K. Ophthalmological and radiological findings in patients of hypertensive crisis reporting to an intensive care setting. Heart India 2023;11:109‑12.

Adake D, Mani UA, Sada E, Shriyan S, Sarangan V, Ursekar R, Singh P. Incidence of Ventricular Fibrillation in Patients presenting with Myocardial Infarction. Hypertension Journal. 2023 Dec 28;9(4):16-7.

Adake D, Singh P, Mani UA, Ursekar R, Sada E, Bhot F, Shriyan SV, Sarangan V. A Clinical Overview of Patients Presenting to ER with Myocardial Infarction Assessed by ESI. National Journal of Emergency Medicine. 2023;1(2):48-51.

Mani UA, Ansari D, Bhot FB, Sada E, Ursekar R. Auto-amputation of an Entire Foot with Ankle in a Diabetic Patient. Advanced Journal of Emergency Medicine. 2019 Aug 17;3(4):e47.

Kumar M, Mani UA, Abbas H, Gupta P. High-Intensity Statins in Acute Coronary Syndrome Part I: A look at the Pharmacological Properties of Statins and Clinical Trials on Statins in ACS. Hypertension Journal. 2023; 9(2): 6-13.

Gupta P, Mani UA, Kumar M, Abbas H. High Intensity Statins in Acute Coronary Syndrome Part 2: A comparison of Atorvastatin and Rosuvastatin for use in ACS, Clinical trials in India and Place for statins in current guidelines. Hypertension Journal. 2023; 9(2): 14-19.

Adake D, Mani UA, Sarangan V, Shriyan S, Sada E, Bhot FB, Ursekar R, Singh P. Prevalence of Hepatitis B, Hepatitis C and HIV in Patients Presenting with Myocardial Infarction to Emergency Department. Indian Journal of Communicable Diseases/Volume. 2023 Jul;9(2).

Tiwari R, Verma S, Verma N, Verma D, Narayan J. Correlation of serum uric acid levels with certain anthropometric parameters in prediabetic and drug-naive diabetic subjects. Annals of African Medicine. 2024 Jan 1;23(1):13-8.

Verma S, Verma A, Kanodia N, Srivastava S, Ansari S, Tewari A, Maheswari A, Srivastava M. Exploring the Synergy Between Hyperuricemia, Obesity, and Hypertension: Evidence from Urban India. Hypertension Journal. 2024 Apr 25;10(1):13-8.

Tiwari R, Singh S, Bajpai M, Verma N, Verma S. Impact of Osteocalcin on Glycemic Regulation and Insulin Sensitivity in Type 2 Diabetes Mellitus Patients. Cureus. 2024 Oct 17;16(10).