Role of miRNAs in Precancerous Oral Lesions and Oral Squamous Cell Carcinoma: A Current Update
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Abstract
Oral cancer can originate from any mouth tissue, including tongue, lip, cheek, floor of the mouth, sinuses, pharynx (throat), and hard & soft palate. Delayed clinical detection, poor prognosis and lack of appropriate treatment strategies are some of the characteristics of this cancer. Epigenetic alteration is a common event in neoplasia. A significant number of current scientific articles have investigated the role of genetic and epigenetic changes in cancer. Among various types of epigenetic events, we sought to explore the epigenetic regulation of miRNAs which has an established role in various cancers. The present article provides a comprehensive review of the literature regarding epigenetic regulations of miRNAs in precancerous oral lesions and oral squamous cell carcinoma.
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