Synthesis, Spectral Properties and Biological Activity of Trivalent Iron and Cobalt Complexes of Schiff Base Ligands Derived from Substituted Isatin and Sulpha Drugs
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Abstract
The generic formula [ML2(H2O)2]Cl used to create a number of novel iron (III) and cobalt (III) complexes using Schiff bases synthesized from substituted isatin and sulphadrugs, by condensing sulpha medicines like sulphamethazine and sulphadiazine with 5-chloroisatin and 5-bromoisatin.
Ligands and compounds have been physically and chemically characterized using elemental, spectroscopic (IR, UV-Vis, PMR) and magnetic examinations. These findings demonstrate that the ligands coordinate with metal ions in a bidentate fashion via phenolic oxygen and imine nitrogen. The complexes exhibit octahedral geometry. Fe(III) complexes are paramagnetic in nature, whereas Co(III) complexes are diamagnetic. Additionally, in vitro research on compounds against fungi and bacteria has been done.
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