Chromium(III), Cobalt(III) and Iron(III) Complexes of NNS Chelating Thiosemicarbazone Ligands: Spectroscopic and Biological Studies

Abstract

Thiosemicarbazones (TSCs) have been emerged as influential category of N,S-donor ligands with an extended time due to structural divergence, donor effectiveness and biological applications. Nitrogen possessing marginal feature can bind with hard-soft transition metal ions while sulphur favours coordination with ions of soft metals. A new series of transition metal complexes of Chromium(lll), Cobalt(III) and Iron(lll) derivatives have been isolated from thiosemicarbazone ligands upon reacting with diacetyl-α-monoxime and unsubstituted/substituted thiosemicarbazone.
The synthesized ligands and complexes were distinguished through physical investigations along with spectral investigation (UV-Vis, IR and 1H NMR). The obtained input illustrates that these complexes have composition of [M(LH)2]Cl·3H2O type and octahedral geometry around central metal ion with N/ S donor atoms. The ligands are of uni-negative tridentate nature. The synthesized trivalent metal complexes appear to be 1:1 electrolyte. In addition, biological studies have been carried out in vitro for investigated compounds