Blood Component Therapy in Sick Newborns

Main Article Content

Taruna Vijaywargiya
Arsheena Athar

Abstract

Background: Sick neonates admitted to NICU (neonatal intensive care unit) frequently need blood component transfusion including WB (whole blood), PRBC (packed red blood cells), FFP (fresh frozen plasma) and platelets.
Aim: This study was aimed to evaluate the indication and frequency of various blood components used in NICU.
Method: This was a retrospective observational study, done at tertiary level NICU in north India. All the neonates admitted in NICU from July 2023 to December 2023 were included and their records were screened for blood component transfused and their indications.
Results: During the study period, out of 141 admissions, 15.6% of newborns required blood component transfusion. PRBC (53.3%) was the most commonly transfused component followed by platelet concentrate (28.9%). 41% of newborns required more than one transfusion. 91.1% of transfusions were appropriate as per our NICU transfusion protocol.
Conclusion: A large number of sick newborns admitted to NICU required blood component transfusion during hospitalization, especially preterm. PRBC, being the most commonly used blood component, should be used appropriately and judiciously.

Article Details

How to Cite
Vijaywargiya, T., & Athar, A. (2024). Blood Component Therapy in Sick Newborns. Journal of Comprehensive Clinical Practice, 18(1), 2–5. Retrieved from https://9vom.in/journals/index.php/jocp/article/view/235
Section
Original Articles

References

Jain R, Jose B, Coshic P, Agarwal R, Deorari AK. Blood and blood component therapy in neonates. Indian J Pediatr. 2008;75(5):489-95.

New H, Berryman J, Bolton-Maggs P, et al. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. 2016;175:784–828.

Agarwal R, Deorari A, Paul VK. In: AIIMS Protocols in Neonatology 3rd ed. New Delhi: CBS Publishers and Distributors. 2024.

New HV, Berryman J, Bolton-Maggs PH, Cantwell C, Chalmers EA, Davies T, et al. Guidelines on transfusion for fetuses, neonates and older children. Br J Haematol. (2016) 175:784–828. doi: 10.1111/bjh.14233

Sparger KA, Assmann SF, Granger S, Winston A, Christensen RD, Widness JA, et al. Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants. JAMA Pediatr 2016;170:687-94.

Cetinkaya M, Atasay B, Perk Y. Turkish neonatal society guideline on the transfusion principles in newborns. Turk Pediatri Ars. (2018) 53:S101–8. doi: 10.5152/TurkPediatriArs.2018.01810

World Health Organization. Blood Transfusion Safety Team. The Clinical Use of Blood: Handbook. Geneva: WHO; 2001.

Harvey G.Klein, David J. “The transfusion of blood, blood components and plasma derivatives” In: Mollison’s Blood transfusion in Clinical Medicine, 11thed, Black well Pub, oxford, 2013.

Dogra K, Kaur G, Basu S, Chawla D: Red cell transfusion practices in neonatal intensive care unit: an experience from tertiary care centre. Indian J Hematol Blood Transfus. 2018, 34:671- 676. 10.1007/s12288-018-0959-4

Kaur A, Shashi Kant Dhir SK, Kaur G, Gupta M,Batta M, component therapy in neonates in a neonatal intensive care unit of northern India, clinical epidemiology and global health 3 (2015) s38–s42

Ayede AI, Akingbola TS. Pattern, indications and review of complications of neonatal blood transfusion in Ibadan, southwest Nigeria. Annals Ibadan Postgrad Med. 2011;9(1):30-6.

Vinayaka P. Hegade, Anjana H. Rao prospective observational study for appropriateness of blood and blood component therapy in children up to 16 years of age admitted to the tertiary care center.Int J Contemp Pediatr.Jan.2019;6(1):110-117

Giridharan J, Ramalingam.G, S.Dhaka; Study of Blood Component Therapy in Neonates. IJSR.2015;4(6):388-393

Amrutiya R J, Mungala B M, Patel V T, et al. (August 23, 2020) Blood Component Transfusion in Tertiary Care Neonatal Intensive Care Unit and Neonatal Intermediate Care Unit: An Audit. Cureus 12(8): e9952. DOI 10.7759/cureus.9952

Sharif M Saxena A Singh S, Manchala S, Jafri NBlood Component Transfusion in a Tertiary Care Hospital,The Indian Journal of Pediatrics (May 2020) 87(5):339–344

Wade M, Sharma R, Manglani M. Rational use of blood compo- nents - an audit. Indian J Hematol Blood Transfus. 2009;25:66–9.

Bahadur S, Sethi N, Pahuja S, Pathak C, Jain M. Audit of pediatric transfusion practices in a tertiary care hospital. Indian J Pediatr. 2015;82:333–9.